منابع مشابه
Metabolism of chemical carcinogens.
The transformation of chemicals is important in carcinogenesis, both in bioactivation and detoxification. Major advances in the past 20 years include appreciation of the migration of reactive electrophiles, the ability of Phase II conjugating enzymes to activate chemicals, understanding of the human enzymes, the realization that DNA modification can result from endogenous chemicals, and the dem...
متن کاملDNA adducts of chemical carcinogens.
Introduction During the 30 years or so following the identification of the first pure chemical carcinogen (1), no common factors or pathways in the mechanism of action of carcinogens from different chemical classes were evident. For this reason perhaps, each class of carcinogen, e.g. the polycyclic aromatic hydrocarbons, the aromatic amines and the nitrosamines, was often reviewed and discussed...
متن کاملChemical Carcinogens and Respiratory Epithelium
In an earlier communication [1], carcinogenic hydrocarbons benzo(a)pyrene (BaP), 7,12-dimethylbenz(a)anthracene (DMBA) and 3-methylcholanthrene (MC) were shown to produce metaplasia and increased proliferation of the epithelium of suckling rat tracheas maintained in organ culture. Tissues exposed for several days by including hydrocarbon in the medium, and tissues so treated and then withdrawn ...
متن کاملChemical carcinogenesis: too many rodent carcinogens.
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinog...
متن کاملReducing occupational exposure to chemical carcinogens.
Strategies for controlling occupational exposure to chemical carcinogens are set out in the European Union Carcinogens Directive and in national legislation such as the British Control of Substances Hazardous to Health Regulations. While such legislative requirements must apply to all occupational chemical carcinogens, it is argued that priority should be given to controlling those agents that ...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/265666a0